VEGF, CD105 and α-SMA immunoexpression study in lips squamous cell carcinomas and associated dysplastic lesions

Rom J Morphol Embryol. 2014;55(1):35-41.

Abstract

This study analyzes the microvascular density (MVD) for CD105+ and α-SMA+ vessels and VEGF immunoexpression for 35 oral squamous cell carcinomas and for the associated dysplastic lesions of the lips. CD105+ MVD was superior in the advancing edge compared to the intratumoral area, no matter the analyzed clinico-pathological parameters (gender, age, differentiation degree, tumor stage) (p<0.05), MVD being significantly higher in poorly differentiated carcinomas (p<0.05). α-SMA+ MVD was also superior in the advancing edge compared to the intratumoral area (p<0.05), MVD values being significantly higher in well and moderately differentiated carcinomas (p<0.05). CD105+ MVD and α-SMA+ MVD were significantly lower compared to the analyzed tumor area (p<0.05), in the dysplastic lesions. VEGF score showed significantly higher values in well to moderately differentiated carcinoma and in the tumor area versus dysplastic associated lesions (p<0.05). CD105+ MVD and VEGF are markers able to characterize the angiogenic phenotype of carcinomas and of the dysplastic lesions of the lips, while α-SMA+ MVD quantification is useful in assessing the vascular maturity degree.

MeSH terms

  • Actins / metabolism*
  • Analysis of Variance
  • Antigens, CD / metabolism*
  • Carcinoma, Squamous Cell / blood supply
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Endoglin
  • Female
  • Humans
  • Immunohistochemistry
  • Lip Neoplasms / blood supply
  • Lip Neoplasms / metabolism*
  • Lip Neoplasms / pathology
  • Male
  • Microvessels / metabolism
  • Microvessels / pathology
  • Middle Aged
  • Receptors, Cell Surface / metabolism*
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • ACTA2 protein, human
  • Actins
  • Antigens, CD
  • ENG protein, human
  • Endoglin
  • Receptors, Cell Surface
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A