An in vivo screen implicates PPP2R2D as an inhibitor of T-cell function

Cancer Discov. 2014 Mar;4(3):OF13. doi: 10.1158/2159-8290.CD-RW2014-032. Epub 2014 Feb 6.

Abstract

The PP2A regulatory subunit PPP2R2D inhibits T-cell proliferation and survival within tumors.

Publication types

  • News

MeSH terms

  • Cell Proliferation
  • Humans
  • Protein Phosphatase 2 / antagonists & inhibitors*
  • RNA, Small Interfering / genetics*
  • T-Lymphocytes / immunology*
  • Tumor Microenvironment

Substances

  • PPP2R2D protein, human
  • RNA, Small Interfering
  • Protein Phosphatase 2