Objective: Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD.
Design and methods: A total of 162 patients with coronary angiography (CAG) proved that CAD was enrolled. Additional 103 patients complained with "chest discomfort" with negative CAG, and 60 normal subjects were enrolled in this study. The levels of plasma vaspin, adiponectin, clinical parameters, lipid profile and C reactive protein (CRP) were measured.
Results: The levels of plasma vaspin were significantly lower in the CAD group (0.47±0.63 μg/L) than those in the healthy group and CAG (-) group (all p<0.001). In CAD group, the pos hoc analysis showed that serum vaspin concentration in acute myocardial infarction group (0.21±0.19 μg/L) was significantly lower than that in the unstable angina pectoris group (0.40±0.37 μg/L) (p=0.012), and serum vaspin concentration in unstable angina pectoris was significantly lower than that in stable angina pectoris group (0.92±0.94 μg/L) (p=0.013). The plasma vaspin concentration was also negatively correlated with the severity of CAD (1-vessel: 0.86±0.90 μg/L; 2-vessel: 0.36±0.39 μg/L; 3-vessel: 0.21±0.16 μg/L). The plasma vaspin concentration in CAG (-) group with "chest discomfort" (1.93±2.57 μg/L) was similar to the healthy control group (2.18±3.49μg/L).
Conclusions: The plasma vaspin concentration correlated to the severity of CAD. Furthermore, plasma vaspin has a value of avoiding patients without CAD from unnecessary CAG.
Keywords: 2-hour post-load plasma glucose; ALT; AMI; Acute coronary syndrome; Acute myocardial infarction; BMI; CAD; CAG; CRP; Coronary artery disease; FPG; HC; HDL-C; HbA1c; LDL-C; LVEF; OR; PG2h; ROC; SAP; SD; TC; TG; TnT; UAP; Vaspin; WBC; acute myocardial infarction; alanine aminotransferase; body mass index; c reactive protein; coronary angiography; coronary artery disease; fasting plasma glucose; glycosylated hemoglobin; healthy control; high-density lipoprotein cholesterol; left ventricular ejection fraction; low-density lipoprotein cholesterol; odd risk; receiver operating characteristic; stable angina pectoris; standard deviation; total cholesterol; triglyceride; troponin T; unstable angina pectoris; white blood cell count.
© 2013.