Correlation of chronic periodontitis in tropical area and IFN-γ, IL-10, IL-17 levels

Asian Pac J Trop Med. 2013 Jun;6(6):489-92. doi: 10.1016/S1995-7645(13)60080-2.

Abstract

Objective: To evaluate the correlation of chronic periodontitis in tropical area and IFN-γ, IL-10 and IL-17 levels.

Methods: One hundred and forty-eight patients and one hundred and thirty-two healthy control subjects were included in the study. Clinical parameters (PI, GI and PD) and GCF levels of IFN-γ, IL-10 and IL-17 were measured at baseline, week 8, week 16 and week 24 after mechanical removal of dental plaque. IFN-γ and IL-10 were determined with ELISA methods and IL-17 was determined with the cytometric bead array.

Results: Removal of dental plaque resulted in improvement in all clinical parameters. Meanwhile, GCF IL-17 declined to control levels, while GCF IFN-γ and IL-10 levels remained unchanged.

Conclusions: The decline of GCF IL-17 levels in patients with resolution of periodontitis suggests that IL-17 is involved in the periodontal inflammatory process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • China / epidemiology
  • Chronic Periodontitis / epidemiology
  • Chronic Periodontitis / immunology*
  • Chronic Periodontitis / therapy
  • Dental Scaling
  • Female
  • Gingival Crevicular Fluid / chemistry
  • Gingival Crevicular Fluid / immunology
  • Humans
  • Interferon-gamma / immunology*
  • Interleukin-10 / immunology*
  • Interleukin-17 / immunology*
  • Male
  • Middle Aged
  • Tropical Climate

Substances

  • IL10 protein, human
  • Interleukin-17
  • Interleukin-10
  • Interferon-gamma