Associations between single-nucleotide polymorphism in the FNDC3A and autism spectrum disorder in a Korean population

Myungja Ro; JungWon Park; Min Nam; Hee Jung Bang; Jae Won Yang; Kyung-Sik Choi; Su Kang Kim; Joo-Ho Chung; KyuBum Kwack

doi:10.1016/j.psychres.2013.02.028

Associations between single-nucleotide polymorphism in the FNDC3A and autism spectrum disorder in a Korean population

Psychiatry Res. 2013 Sep 30;209(2):246-8. doi: 10.1016/j.psychres.2013.02.028. Epub 2013 Apr 29.

Authors

Myungja Ro¹, JungWon Park, Min Nam, Hee Jung Bang, Jae Won Yang, Kyung-Sik Choi, Su Kang Kim, Joo-Ho Chung, KyuBum Kwack

Affiliation

¹ Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Republic of Korea.

PMID: 23639254
DOI: 10.1016/j.psychres.2013.02.028

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental syndrome associated with impairments of reciprocal communication and cognitive function. Associations between single-nucleotide polymorphisms (SNPs) and ASD were analysed by logistic regression. Polymorphisms in fibronectin type III domain-containing 3A (FNDC3A) exhibited significant associations in genotype and diplotype analyses. We conclude that FNDC3A influences the prevalence of ASD.

Keywords: ASD; Fibronectin type III domain-containing 3A (FNDC3A); SNP.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Child Development Disorders, Pervasive / genetics*
Female
Fibronectins / genetics*
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Linkage Disequilibrium
Logistic Models
Male
Polymorphism, Single Nucleotide / genetics*
Republic of Korea
Retrospective Studies

Substances

FNDC3A protein, human
Fibronectins