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Activation of DSB processing requires phosphorylation of CtIP by ATR.
Mol Cell. 2013 Feb 21;49(4):657-67. doi: 10.1016/j.molcel.2012.11.020. Epub 2012 Dec 27.
Mol Cell. 2013.
PMID: 23273981
Free PMC article.
Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.
Deshpande RA, Lee JH, Arora S, Paull TT.
Deshpande RA, et al.
Mol Cell. 2016 Nov 3;64(3):593-606. doi: 10.1016/j.molcel.2016.10.010.
Mol Cell. 2016.
PMID: 27814491
Free article.
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Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection.
Anand R, Ranjha L, Cannavo E, Cejka P.
Anand R, et al.
Mol Cell. 2016 Dec 1;64(5):940-950. doi: 10.1016/j.molcel.2016.10.017. Epub 2016 Nov 23.
Mol Cell. 2016.
PMID: 27889449
Free article.
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NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation.
Anand R, Jasrotia A, Bundschuh D, Howard SM, Ranjha L, Stucki M, Cejka P.
Anand R, et al.
EMBO J. 2019 Apr 1;38(7):e101005. doi: 10.15252/embj.2018101005. Epub 2019 Feb 20.
EMBO J. 2019.
PMID: 30787182
Free PMC article.
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