Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population

Parkinsonism Relat Disord. 2013 Apr;19(4):446-7. doi: 10.1016/j.parkreldis.2012.11.016. Epub 2012 Dec 8.

Abstract

Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry. But there have been no studies investigating the association between angiogenin and Parkinson's disease in the ethnic Chinese population. We conducted a case-control study to evaluate the association between angiogenin and Parkinson's disease in a Chinese population from mainland China. We sequenced the exons of angiogenin in 532 Parkinson's disease patients and 480 controls. We did not detect an angiogenin coding region mutation in either the patients or the controls. Our data do not support the association of angiogenin variants with PD in Han Chinese of mainland China.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian People / genetics
  • Case-Control Studies
  • China / epidemiology
  • DNA Mutational Analysis
  • Ethnicity / genetics
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics
  • Genetic Variation
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ribonuclease, Pancreatic / genetics*
  • Young Adult

Substances

  • angiogenin
  • Ribonuclease, Pancreatic