Abstract
The literature data concerning structure of cyclo-oxigenase-1--the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.
MeSH terms
-
Alleles
-
Aspirin / pharmacology
-
Aspirin / therapeutic use*
-
Blood Platelets / drug effects
-
Cyclooxygenase 1 / genetics
-
Cyclooxygenase 1 / metabolism*
-
Cyclooxygenase Inhibitors / pharmacology
-
Cyclooxygenase Inhibitors / therapeutic use*
-
Drug Resistance
-
Gene Frequency
-
Humans
-
Inflammation / drug therapy*
-
Inflammation / enzymology
-
Inflammation / genetics
-
Isoenzymes / genetics
-
Isoenzymes / metabolism
-
Platelet Aggregation / drug effects
-
Platelet Aggregation Inhibitors / pharmacology
-
Platelet Aggregation Inhibitors / therapeutic use*
-
Polymorphism, Genetic*
-
Prostaglandins / biosynthesis
Substances
-
Cyclooxygenase Inhibitors
-
Isoenzymes
-
Platelet Aggregation Inhibitors
-
Prostaglandins
-
Cyclooxygenase 1
-
PTGS1 protein, human
-
Aspirin