[Cyclooxigenase-1 gene polymorphism and aspirin resistance]

Tsitol Genet. 2012 Jul-Aug;46(4):66-72.
[Article in Russian]

Abstract

The literature data concerning structure of cyclo-oxigenase-1--the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Alleles
  • Aspirin / pharmacology
  • Aspirin / therapeutic use*
  • Blood Platelets / drug effects
  • Cyclooxygenase 1 / genetics
  • Cyclooxygenase 1 / metabolism*
  • Cyclooxygenase Inhibitors / pharmacology
  • Cyclooxygenase Inhibitors / therapeutic use*
  • Drug Resistance
  • Gene Frequency
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / enzymology
  • Inflammation / genetics
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Polymorphism, Genetic*
  • Prostaglandins / biosynthesis

Substances

  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Platelet Aggregation Inhibitors
  • Prostaglandins
  • Cyclooxygenase 1
  • PTGS1 protein, human
  • Aspirin