Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection

J Acquir Immune Defic Syndr. 2012 Feb 1;59(2):121-5. doi: 10.1097/QAI.0b013e3182392ebe.

Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adult
  • Apoptosis Regulatory Proteins / genetics
  • Brazil
  • CARD Signaling Adaptor Proteins / genetics
  • Calcium-Binding Proteins / genetics
  • Carrier Proteins / genetics
  • Caspase 1 / genetics
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • HIV Infections / genetics*
  • HIV-1*
  • Humans
  • Inflammasomes / genetics*
  • Interleukin-1beta / genetics
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Male
  • Middle Aged
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLR Proteins
  • Neoplasm Proteins / genetics
  • Polymorphism, Single Nucleotide*

Substances

  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • CARD Signaling Adaptor Proteins
  • CARD8 protein, human
  • Calcium-Binding Proteins
  • Carrier Proteins
  • IL1B protein, human
  • Inflammasomes
  • Interleukin-1beta
  • Intracellular Signaling Peptides and Proteins
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLR Proteins
  • NLRC4 protein, human
  • NLRP1 protein, human
  • NLRP3 protein, human
  • Neoplasm Proteins
  • Caspase 1