Migraine: Role of the TRESK two-pore potassium channel

Int J Biochem Cell Biol. 2011 Nov;43(11):1533-6. doi: 10.1016/j.biocel.2011.08.002. Epub 2011 Aug 9.

Abstract

Migraine is a severe episodic headache disorder affecting one in five people. Genetic studies have identified mutations in the CACNA1, ATP1A2 and SCN1A genes in the rare familial hemiplegic migraine. Recently, a mutation in the KCNK18 gene, encoding the TRESK two-pore domain potassium channel, was described in a large family with migraine with aura. This review will elaborate on the possible role of the TRESK channel in regulating neuronal excitability, its role in migraine pathogenesis, and on promising therapeutic opportunities targeting this channel.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Calcineurin / metabolism
  • Calcium / metabolism
  • Epilepsy / complications
  • Epilepsy / drug therapy
  • Epilepsy / genetics*
  • Epilepsy / pathology
  • Frameshift Mutation*
  • Gene Expression
  • Humans
  • Mice
  • Mice, Knockout
  • Migraine Disorders / complications
  • Migraine Disorders / drug therapy
  • Migraine Disorders / genetics*
  • Migraine Disorders / pathology
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / metabolism
  • Potassium / metabolism*
  • Potassium Channels / genetics*
  • Potassium Channels / metabolism
  • Protein Multimerization
  • Protein Structure, Tertiary
  • Serotonin Receptor Agonists / therapeutic use
  • Tryptamines / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • KCNK18 protein, human
  • Nerve Tissue Proteins
  • Potassium Channels
  • Serotonin Receptor Agonists
  • Tryptamines
  • Calcineurin
  • Potassium
  • Calcium