Gpc-3 is a notable diagnostic, prognostic and a latent targeted therapy marker in hepatocellular carcinoma

Hepatogastroenterology. 2010 Sep-Oct;57(102-103):1285-90.

Abstract

Background/aims: To describe the features of the Gpc-3, explore the significance and value about the role of Gpc-3 in pathological diagnosis and prognostic evaluation of hepatocellular carcinoma.

Methodology: Take an overview of Gpc-3 expression in hepatocellular carcinoma and its expression of the relationship between the clinicopathological features of hepatocellular carcinoma, analysis the expression of Gpc-3 in liver cell adenoma, heterosexual hyperplasia and hepatitis C.

Results: The expression of GPC-3 has a certain amount of specificity and sensitivity in hepatocellular carcinoma.

Conclusions: Gpc-3 is not only a diagnostic and prognostic marker in hepatocellular carcinoma, but also is expected to be an ideal target for the therapy of hepatocellular carcinoma.

Publication types

  • Review

MeSH terms

  • Adenoma / chemistry
  • Biomarkers, Tumor / analysis*
  • Carcinoma, Hepatocellular / chemistry
  • Carcinoma, Hepatocellular / diagnosis*
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / pathology
  • Cell Proliferation
  • Glypicans / analysis*
  • Glypicans / genetics
  • Hepatitis C / metabolism
  • Humans
  • Liver Neoplasms / chemistry
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology
  • Prognosis

Substances

  • Biomarkers, Tumor
  • GPC3 protein, human
  • Glypicans