[Study of the genes expression of SCD-2 and B-FABP in the mice brain of exercise-induced fatigue by genechip cDNA microarray]

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 May;21(2):137-9.
[Article in Chinese]

Abstract

Aim: By genechip cDNA microarray, the genes expressions of Stearoyl-coenzyme A desaturase (Scd-2) and brain fatty acid-binding protein (B-FABP) were studied in the central nervous system (CNS) of the mice to discuss the mechanism of exercise-induced fatigue.

Methods: Building the model of fatigued animal and using the genechip cDNA microarray, the genes expressions were analyzed between the control group and fatigue group mice.

Results: The genes expression of Scd-2 and B-FABP were obvious different in the brain of fatigued group mice than of control group.

Conclusion: Exercise-induced nerve center fatigue is correlated with genes expressions of lipid metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Brain / metabolism*
  • Fatigue / genetics
  • Fatigue / metabolism*
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins / genetics
  • Fatty Acid-Binding Proteins / metabolism*
  • Gene Expression
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Oligonucleotide Array Sequence Analysis
  • Stearoyl-CoA Desaturase / genetics
  • Stearoyl-CoA Desaturase / metabolism*

Substances

  • Fabp7 protein, rat
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Nerve Tissue Proteins
  • Stearoyl-CoA Desaturase