Genomic sequence and organization of two members of a human lectin gene family

Biochemistry. 1991 Jan 8;30(1):82-9. doi: 10.1021/bi00215a013.

Abstract

We have isolated and sequenced the genomic DNA encoding a human dimeric soluble lactose-binding lectin. The gene has four exons, and its upstream region contains sequences that suggest control by glucocorticoids, heat (environmental) shock, metals, and other factors. We have also isolated and sequenced three exons of the gene encoding another human putative lectin, the existence of which was first indicated by isolation of its cDNA. Comparisons suggest a general pattern of genomic organization of members of this lectin gene family.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Chromosome Deletion
  • Cloning, Molecular
  • Cosmids
  • DNA / genetics
  • DNA / isolation & purification
  • DNA Probes
  • Genomic Library
  • Humans
  • Lectins / genetics*
  • Leukocytes / immunology
  • Molecular Sequence Data
  • Multigene Family*
  • Oligonucleotide Probes
  • Polymerase Chain Reaction
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid

Substances

  • DNA Probes
  • Lectins
  • Oligonucleotide Probes
  • DNA

Associated data

  • GENBANK/J05303
  • GENBANK/M32239
  • GENBANK/M57678
  • GENBANK/M61856
  • GENBANK/M61857
  • GENBANK/M62350
  • GENBANK/M62351
  • GENBANK/M62352
  • GENBANK/M62353
  • GENBANK/M62354
  • GENBANK/M64931