Abstract
The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data. We will also present results of transcriptome analyses, which have highlighted different categories of LIF targets, identified in murine embryonic stem (ES) cells and early derivatives. We hope to stimulate new research fields on this puzzling cytokine, which, forty years after its discovery, has still not disclosed all its secrets.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation / physiology
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Embryo Implantation / physiology
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / metabolism
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Exostoses, Multiple Hereditary / genetics
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Developmental
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Humans
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Infertility, Female / metabolism
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Leukemia Inhibitory Factor / physiology*
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Leukemia Inhibitory Factor Receptor alpha Subunit / deficiency
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Leukemia Inhibitory Factor Receptor alpha Subunit / genetics
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Mice
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Osteochondrodysplasias / genetics
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Pluripotent Stem Cells / cytology
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Pluripotent Stem Cells / metabolism
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Pregnancy
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Receptors, OSM-LIF / classification
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Receptors, OSM-LIF / physiology
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STAT3 Transcription Factor / physiology
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Signal Transduction
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Species Specificity
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Suppressor of Cytokine Signaling 3 Protein
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Suppressor of Cytokine Signaling Proteins / physiology
Substances
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LIF protein, human
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Leukemia Inhibitory Factor
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Leukemia Inhibitory Factor Receptor alpha Subunit
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Lif protein, mouse
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Receptors, OSM-LIF
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SOCS3 protein, human
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STAT3 Transcription Factor
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STAT3 protein, human
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Socs3 protein, mouse
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Stat3 protein, mouse
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Suppressor of Cytokine Signaling 3 Protein
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Suppressor of Cytokine Signaling Proteins