Vaspin and its correlation with insulin sensitivity indices in obese children

Diabetes Res Clin Pract. 2009 Jun;84(3):325-8. doi: 10.1016/j.diabres.2009.03.008. Epub 2009 Apr 7.

Abstract

Aim: The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents.

Material and methods: Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sensitivity and lipids were analyzed in 33 pubertal obese children (19 girls and 14 boys) and 36 healthy control children (18 girls and 18 boys) aged 11-16 years. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR) and fasting glucose-to-insulin ratio (FGIR). Plasma vaspin and adiponectin concentrations were determined with radioimmunoassay.

Results: Mean vaspin levels were found significantly higher and inversely, adiponectin levels were found significantly lower in obese pubertal group than control subjects. Vaspin levels were positively correlated with BMI-SDS, triglycerides, fasting insulin and HOMA-IR and negatively correlated with adiponectin levels and FGIR. Adiponectin levels were positively correlated with high density lipoprotein-chloesterol, FGIR and negatively correlated with vaspin, BMI-SDS, fasting insulin and HOMA-IR.

Conclusion: We found higher vaspin and lower adiponectin levels in obese children and these adipokines were significantly correlated with insulin sensitivity indices in this age.

MeSH terms

  • Adiponectin / blood
  • Adolescent
  • Blood Glucose / analysis
  • Body Height
  • Body Mass Index
  • Body Weight
  • Child
  • Fasting
  • Female
  • Humans
  • Insulin / blood
  • Lipids / blood
  • Male
  • Obesity / blood*
  • Reference Values
  • Serpins / blood*

Substances

  • Adiponectin
  • Blood Glucose
  • Insulin
  • Lipids
  • SERPINA12 protein, human
  • Serpins