Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

Christine L E Siezen; Louis Bont; Hennie M Hodemaekers; Marieke J Ermers; Gerda Doornbos; Ruben Van't Slot; Ciska Wijmenga; Hans C van Houwelingen; Jan L L Kimpen; Tjeerd G Kimman; Barbara Hoebee; Riny Janssen

doi:10.1097/INF.0b013e31818e2aa9

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

Pediatr Infect Dis J. 2009 Apr;28(4):333-5. doi: 10.1097/INF.0b013e31818e2aa9.

Authors

Christine L E Siezen¹, Louis Bont, Hennie M Hodemaekers, Marieke J Ermers, Gerda Doornbos, Ruben Van't Slot, Ciska Wijmenga, Hans C van Houwelingen, Jan L L Kimpen, Tjeerd G Kimman, Barbara Hoebee, Riny Janssen

Affiliation

¹ Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

PMID: 19258923
DOI: 10.1097/INF.0b013e31818e2aa9

Abstract

Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.

MeSH terms

ADAM Proteins / genetics
Bronchiolitis, Viral / genetics*
Cohort Studies
Data Interpretation, Statistical
Genetic Predisposition to Disease*
Humans
Immunity, Innate / genetics*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / genetics*
Lung / growth & development
Polymorphism, Single Nucleotide
Protein Serine-Threonine Kinases / genetics
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta / genetics
Respiratory Syncytial Virus Infections / genetics*
Risk Factors

Substances

Receptors, Transforming Growth Factor beta
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type I
TGFBR1 protein, human
ADAM Proteins
ADAM33 protein, human