Association study between B- and T-lymphocyte attenuator gene and type 1 diabetes mellitus or systemic lupus erythematosus in the Japanese population

M Inuo; K Ihara; T Matsuo; H Kohno; T Hara

doi:10.1111/j.1744-313X.2008.00809.x

Association study between B- and T-lymphocyte attenuator gene and type 1 diabetes mellitus or systemic lupus erythematosus in the Japanese population

Int J Immunogenet. 2009 Feb;36(1):65-8. doi: 10.1111/j.1744-313X.2008.00809.x.

Authors

M Inuo¹, K Ihara, T Matsuo, H Kohno, T Hara

Affiliation

¹ Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka, Japan. mikam@pediatr.med.kyushu-u.ac.jp

PMID: 19207938
DOI: 10.1111/j.1744-313X.2008.00809.x

Abstract

This study is to elucidate whether the B- and T-lymphocyte attenuator (BTLA) gene is a new susceptibility gene for the development of type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). As a result, this study did not find any genetic contribution of the BTLA gene to the development of T1D and SLE in Japanese population.

MeSH terms

Alleles
B-Lymphocytes / metabolism
Child
Diabetes Mellitus, Type 1 / genetics*
Gene Frequency / genetics
Genetic Predisposition to Disease*
Genotype
Haplotypes / genetics
Humans
Lupus Erythematosus, Systemic / genetics*
Polymorphism, Single Nucleotide / genetics
Receptors, Immunologic / genetics*
T-Lymphocytes / metabolism

Substances

BTLA protein, human
Receptors, Immunologic