Abstract
Eczema does not occur in the absence of T cells. Here we provide an overview on the regulatory impact which T cells have on the establishment and maintenance of atopic dermatitis. Particularly, we outline the role of different T-helper cell subsets (i.e. Th-1, Th-2, T-regulatory and Th-17 cells) and their distinct influence on the cutaneous inflammatory reaction at different stages of the disease. Eczema is characterized by epidermal inflammation and thus T-cell/ker - atinocyte interactions are of particular relevance in this condition. Alterations in innate and adaptive immunity involving T cells result in susceptibility to skin infections and in hyperreactivity reactions to environmental stimuli which in turn determine the course and severity of atopic dermatitis.
MeSH terms
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Animals
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Antimicrobial Cationic Peptides / immunology
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Bacterial Infections / complications
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Bacterial Infections / genetics
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Bacterial Infections / immunology
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Cell Movement / immunology
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Cytokines / immunology
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Cytokines / metabolism
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Dermatitis, Atopic / etiology
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Dermatitis, Atopic / genetics
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Dermatitis, Atopic / immunology*
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Dermatitis, Atopic / pathology
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Desensitization, Immunologic
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Eczema / immunology
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Food Hypersensitivity / complications
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Food Hypersensitivity / genetics
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Food Hypersensitivity / immunology
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Food Hypersensitivity / therapy
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / immunology
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Forkhead Transcription Factors / metabolism*
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Genetic Predisposition to Disease
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Humans
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Keratinocytes / immunology
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Keratinocytes / metabolism*
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Keratinocytes / pathology
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RANK Ligand / immunology
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T-Lymphocytes, Helper-Inducer / immunology
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T-Lymphocytes, Helper-Inducer / metabolism*
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T-Lymphocytes, Helper-Inducer / pathology
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T-Lymphocytes, Regulatory / immunology
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T-Lymphocytes, Regulatory / metabolism*
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T-Lymphocytes, Regulatory / pathology
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Thymic Stromal Lymphopoietin
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Toll-Like Receptors / immunology
Substances
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Antimicrobial Cationic Peptides
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Cytokines
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FOXP3 protein, human
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Forkhead Transcription Factors
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RANK Ligand
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Toll-Like Receptors
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Thymic Stromal Lymphopoietin