KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease

Ralph D Levinson; Zeying Du; Lihui Luo; Gary N Holland; Narsing A Rao; Elaine F Reed; Raja Rajalingam

doi:10.1016/j.humimm.2008.04.005

KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease

Hum Immunol. 2008 Jun;69(6):349-53. doi: 10.1016/j.humimm.2008.04.005. Epub 2008 May 9.

Authors

Ralph D Levinson¹, Zeying Du, Lihui Luo, Gary N Holland, Narsing A Rao, Elaine F Reed, Raja Rajalingam

Affiliation

¹ Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA.

PMID: 18571006
DOI: 10.1016/j.humimm.2008.04.005

Abstract

Vogt-Koyanagi-Harada (VKH) disease is a putative autoimmune ocular inflammatory disease and is known to be associated with HLA-DR4 and -DR1 in Mestizos. We examined the genes encoding KIR receptors and human leukocyte antigen (HLA) class I ligands in patients with VKH disease and compared to published controls. We found trends toward more group B KIR haplogroups (p=0.059), with more activating KIR genes, in patients compared to controls. All putative activating KIR-HLA combinations were more common in patients, and some inhibitory KIR-HLA combinations were more common in controls, although the differences were not statistically significant. The trends observed in this study are consistent with those reported for other autoimmune diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

California / ethnology
Female
Gene Frequency
Genetic Predisposition to Disease
HLA-DR Antigens / analysis
HLA-DR Antigens / genetics*
Haplotypes
Humans
Indians, North American*
Male
Protein Interaction Domains and Motifs / genetics
Protein Interaction Domains and Motifs / immunology
Receptors, KIR / genetics*
Uveomeningoencephalitic Syndrome / ethnology
Uveomeningoencephalitic Syndrome / genetics*

Substances

HLA-DR Antigens
Receptors, KIR