Abstract
The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases' and controls' family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN *2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / ethnology
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Adenocarcinoma / genetics*
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Adenocarcinoma / microbiology
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Adult
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Aged
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Asian People / genetics*
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Case-Control Studies
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China / epidemiology
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Female
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Gene Frequency
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Genetic Predisposition to Disease
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Haplotypes
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Helicobacter Infections / complications
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Helicobacter Infections / microbiology
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Helicobacter pylori / isolation & purification
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Humans
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Inflammation / ethnology
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Inflammation / genetics*
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Inflammation / microbiology
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Interleukin 1 Receptor Antagonist Protein / genetics*
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Interleukin-1beta / genetics*
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Logistic Models
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Male
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Middle Aged
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Minisatellite Repeats
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Odds Ratio
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Polymorphism, Genetic*
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Prevalence
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Risk Assessment
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Risk Factors
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Stomach Neoplasms / ethnology
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Stomach Neoplasms / genetics*
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Stomach Neoplasms / microbiology
Substances
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1beta