Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg)

Stephan von Gunten; Hans-Uwe Simon

doi:10.1016/j.autrev.2008.03.015

Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg)

Autoimmun Rev. 2008 Jun;7(6):453-6. doi: 10.1016/j.autrev.2008.03.015. Epub 2008 Apr 18.

Authors

Stephan von Gunten¹, Hans-Uwe Simon

Affiliation

¹ Institute of Pathology, University Hospital Basel, Basel, Switzerland. sgunten@yahoo.com

PMID: 18558361
DOI: 10.1016/j.autrev.2008.03.015

Abstract

Human intravenous immunoglobulins (IVIg) contain natural autoantibodies against the inhibitory lectin-receptors Siglec-8 and Siglec-9. These two members of the Siglec family are known to mediate both inhibitory and death signals. Here, we discuss recent findings regarding the cytotoxic effects of natural anti-Siglec autoantibodies on both neutrophils and eosinophils, and present the concept of a novel regulatory mechanism exhibiting anti-inflammatory properties. Consequently, IVIg may amplify this regulatory pathway by increasing the concentration of natural anti-Siglec autoantibodies in blood and tissues.

Publication types

Review

MeSH terms

Antigens, CD / immunology*
Antigens, CD / physiology
Antigens, Differentiation, B-Lymphocyte / immunology*
Antigens, Differentiation, B-Lymphocyte / physiology
Autoantibodies / immunology
Autoantibodies / toxicity*
Eosinophils / drug effects
Humans
Immunoglobulins, Intravenous / toxicity*
Lectins / antagonists & inhibitors
Lectins / immunology*
Lectins / physiology
Neutrophils / drug effects
Sialic Acid Binding Immunoglobulin-like Lectins

Substances

Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Autoantibodies
Immunoglobulins, Intravenous
Lectins
SIGLEC8 protein, human
SIGLEC9 protein, human
Sialic Acid Binding Immunoglobulin-like Lectins