The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14

Ann Hum Genet. 1991 Oct;55(4):273-8. doi: 10.1111/j.1469-1809.1991.tb00853.x.

Abstract

Ubiquitin carboxy terminal hydrolase 1, UCHL1, is a neurone-specific protein involved in the ubiquitin-mediated proteolytic pathway. The gene for human UCHL1 has been mapped to chromosome 4 using the polymerase chain reaction to amplify specifically the human UCHL1 sequences in rodent/human somatic cell hybrid DNA. A regional assignment of this locus to 4p14 has been made by in situ hybridization to metaphase chromosomes using both tritium and fluorescently labelled probes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Banding
  • Chromosomes, Human, Pair 4*
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Thiolester Hydrolases / genetics*
  • Ubiquitin Thiolesterase

Substances

  • Thiolester Hydrolases
  • Ubiquitin Thiolesterase