Histamine receptor H4R-selective ligands influence the STAT6 Transcription Activation Domain (TAD) and the DNA-binding

Inflamm Res. 2008:57 Suppl 1:S47-8. doi: 10.1007/s00011-007-0623-1.

Authors

I Michel¹, H Borck, S McElligott, C Krieg, F Diel

Affiliation

¹ Institut für Umwelt und Gesundheit (IUG) and University of Applied Sciences, FB Oe, Biochemistry, Marquardstrasse 35, D-36039 Fulda, Germany.

PMID: 18345495
DOI: 10.1007/s00011-007-0623-1

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Benzimidazoles / metabolism
DNA / metabolism*
Female
Histamine Antagonists / metabolism
Humans
Indoles / metabolism
Jurkat Cells
Leukocytes, Mononuclear / metabolism
Ligands
Piperazines / metabolism
Protein Structure, Tertiary
Receptors, G-Protein-Coupled / metabolism*
Receptors, Histamine / metabolism*
Receptors, Histamine H4
STAT6 Transcription Factor / genetics*
STAT6 Transcription Factor / metabolism
Transcriptional Activation*

Substances

Benzimidazoles
HRH4 protein, human
Histamine Antagonists
Indoles
JNJ 10191584
Ligands
Piperazines
Receptors, G-Protein-Coupled
Receptors, Histamine
Receptors, Histamine H4
STAT6 Transcription Factor
STAT6 protein, human
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine
DNA