Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis

Psychiatry Res. 2008 Feb 28;162(2):167-71. doi: 10.1016/j.pscychresns.2007.10.001. Epub 2008 Jan 3.

Abstract

Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients. We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Base Pairing
  • Brain / pathology*
  • Gene Frequency / genetics
  • Genetic Carrier Screening
  • Genotype*
  • Homozygote
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / genetics*
  • Longitudinal Studies
  • Magnetic Resonance Imaging*
  • Occipital Lobe / pathology
  • Polymorphism, Genetic / genetics*
  • Prospective Studies
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / genetics*
  • Psychotic Disorders / pathology
  • Repetitive Sequences, Nucleic Acid / genetics
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*
  • Schizophrenia / pathology

Substances

  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein