Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

Masafumi Tsujimoto; Yoshikuni Goto; Masato Maruyama; Akira Hattori

doi:10.1007/s10741-007-9064-8

Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

Heart Fail Rev. 2008 Sep;13(3):285-91. doi: 10.1007/s10741-007-9064-8. Epub 2007 Nov 13.

Authors

Masafumi Tsujimoto¹, Yoshikuni Goto, Masato Maruyama, Akira Hattori

Affiliation

¹ Laboratory of Cellular Biochemistry, Saitama, Japan, tsujimot@riken.jp

PMID: 17999179
DOI: 10.1007/s10741-007-9064-8

Abstract

It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)(18)E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aminopeptidases / chemistry
Aminopeptidases / metabolism*
Blood Pressure / physiology*
CD13 Antigens / chemistry
CD13 Antigens / metabolism
Catalysis
Cystinyl Aminopeptidase / chemistry
Cystinyl Aminopeptidase / metabolism
Glutamyl Aminopeptidase / chemistry
Glutamyl Aminopeptidase / metabolism
Humans
Hypertension / enzymology*
Hypertension / physiopathology
Models, Biological

Substances

Aminopeptidases
CD13 Antigens
Cystinyl Aminopeptidase
leucyl-cystinyl aminopeptidase
Glutamyl Aminopeptidase