Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Med Mycol. 2007 Sep;45(6):513-8. doi: 10.1080/13693780701390140.

Abstract

A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Antigens, CD / genetics*
  • Case-Control Studies
  • Cryptococcosis / epidemiology
  • Cryptococcosis / genetics*
  • Cryptococcus neoformans
  • Female
  • GPI-Linked Proteins
  • Genetic Predisposition to Disease
  • Genotype
  • HIV Seronegativity*
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Polymorphism, Genetic*
  • Receptors, IgG / genetics*
  • Risk Factors
  • White People

Substances

  • Antigens, CD
  • FCGR2A protein, human
  • FCGR3A protein, human
  • FCGR3B protein, human
  • GPI-Linked Proteins
  • Receptors, IgG