[Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia carcinoma]

Zhonghua Wei Chang Wai Ke Za Zhi. 2007 Jul;10(4):380-2.
[Article in Chinese]

Abstract

Objective: To investigate the expression and clinical significance of KiSS- 1 and E- cadherin in gastric cardia carcinoma and the correlation between the two proteins.

Methods: The expression of KiSS- 1 and E- cadherin in 80 patients with gastric cardia carcinoma and 20 patients with normal gastric cardia epithelium was detected by immunohistochemical technique.

Results: The expression of KiSS- 1 was negatively correlated with lymphatic metastasis and clinical stage (P < 0.05), but not correlated with the cancer differentiation (P < 0.05). The expression of E- cadherin was negatively correlated with lymphatic metastasis, clinical stage, and cancer differentiation (P < 0.05). Spearman test showed a positive correlation between KiSS- 1 and E- cadherin expression (r(s)=0.722, P < 0.05).

Conclusion: KiSS- 1 and E- cadherin may play important roles in inhibiting the invasion and metastasis of gastric cardia carcinoma.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cadherins / metabolism*
  • Cardia / pathology
  • Female
  • Humans
  • Kisspeptins
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / pathology
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Cadherins
  • KISS1 protein, human
  • Kisspeptins
  • Tumor Suppressor Proteins