Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?

Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):892-4. doi: 10.1158/1055-9965.EPI-06-0965.

Abstract

Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Chromosomes, Human, Pair 9*
  • Colorectal Neoplasms / genetics*
  • Family
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Male
  • Protein Serine-Threonine Kinases / genetics*
  • Receptor, Transforming Growth Factor-beta Type I
  • Receptors, Transforming Growth Factor beta / genetics*
  • Regression Analysis

Substances

  • Receptors, Transforming Growth Factor beta
  • Protein Serine-Threonine Kinases
  • Receptor, Transforming Growth Factor-beta Type I
  • TGFBR1 protein, human