Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

Cancer Metastasis Rev. 2007 Mar;26(1):5-14. doi: 10.1007/s10555-007-9039-1.

Abstract

The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokines, CC
  • Drug Resistance, Neoplasm* / genetics
  • Macrophage Inflammatory Proteins / genetics
  • Macrophage Inflammatory Proteins / physiology*
  • Mice
  • Mice, Knockout
  • Multidrug Resistance-Associated Proteins / genetics
  • Multidrug Resistance-Associated Proteins / physiology*

Substances

  • Abcc4 protein, mouse
  • Ccl9 protein, mouse
  • Chemokines, CC
  • Macrophage Inflammatory Proteins
  • Multidrug Resistance-Associated Proteins
  • multidrug resistance-associated protein 3