Abstract
Interaction with antigen-presenting accessory cells is thought to be an important step in B-cell activation, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antigens, CD / genetics
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Antigens, CD / immunology*
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Antigens, Differentiation, B-Lymphocyte / genetics
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Antigens, Differentiation, B-Lymphocyte / immunology*
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B-Lymphocytes / immunology*
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Base Sequence
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Cell Adhesion / immunology
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Cell Adhesion Molecules*
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Cloning, Molecular
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Erythrocytes / immunology*
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Immunosorbent Techniques
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Lectins*
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Molecular Sequence Data
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Molecular Weight
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Monocytes / immunology*
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Nucleic Acid Hybridization
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RNA / analysis
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Receptors, Antigen, B-Cell / immunology
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Recombinant Proteins / immunology
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Rosette Formation
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Sequence Homology, Nucleic Acid
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Sialic Acid Binding Ig-like Lectin 2
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Transfection
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Tumor Cells, Cultured
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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Cell Adhesion Molecules
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Lectins
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Receptors, Antigen, B-Cell
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Recombinant Proteins
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Sialic Acid Binding Ig-like Lectin 2
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RNA