Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia

E G Shchepotina; M V Nikishina; V A Vavilin; V V Lyakhovich

doi:10.1007/s10517-006-0067-6

Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia

Bull Exp Biol Med. 2005 Dec;140(6):726-8. doi: 10.1007/s10517-006-0067-6.

Authors

E G Shchepotina¹, M V Nikishina, V A Vavilin, V V Lyakhovich

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.

PMID: 16848237
DOI: 10.1007/s10517-006-0067-6

Abstract

Analysis of restriction fragment length polymorphism is proposed for detecting CYP3A43 gene c1047 > T mutation. The incidence of this mutation (CYP3A43*1B allele) was evaluated in 102 europeoid residents of West Siberia and it was found to be 12.25%.

MeSH terms

Adolescent
Alleles*
Aryl Hydrocarbon Hydroxylases / genetics*
Child
Child, Preschool
DNA Mutational Analysis
Female
Gene Frequency
Genetics, Population
Heterozygote
Homozygote
Humans
Infant
Male
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length*
Siberia
White People

Substances

Aryl Hydrocarbon Hydroxylases
CYP3A43 protein, human