Cloning and chromosomal localization of a human endothelin ETA receptor

Biochem Biophys Res Commun. 1991 Nov 27;181(1):184-90. doi: 10.1016/s0006-291x(05)81399-3.

Abstract

A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cattle
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4*
  • Cloning, Molecular / methods
  • Endothelins / metabolism
  • Humans
  • Hybrid Cells / physiology
  • Molecular Sequence Data
  • Plasmids
  • Polymerase Chain Reaction
  • Rats
  • Receptors, Cell Surface / genetics*
  • Receptors, Endothelin
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid

Substances

  • Endothelins
  • Receptors, Cell Surface
  • Receptors, Endothelin