Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

Circ J. 2006 Mar;70(3):362-3. doi: 10.1253/circj.70.362.

Abstract

Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF).

Methods and results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05).

Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.

MeSH terms

  • Adult
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Biomarkers / blood
  • Female
  • G-Protein-Coupled Receptor Kinase 1 / analysis
  • G-Protein-Coupled Receptor Kinase 1 / genetics*
  • G-Protein-Coupled Receptor Kinase 1 / metabolism
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Heart Failure / drug therapy
  • Heart Failure / enzymology*
  • Heart Failure / genetics*
  • Humans
  • Lymphocytes / chemistry
  • Lymphocytes / enzymology
  • Male
  • Middle Aged
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Receptors, Adrenergic, beta / drug effects
  • Receptors, Adrenergic, beta / physiology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Severity of Illness Index

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Biomarkers
  • RNA, Messenger
  • Receptors, Adrenergic, beta
  • G-Protein-Coupled Receptor Kinase 1