Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis

Eur J Pharmacol. 2005 Jun 1;516(2):180-1. doi: 10.1016/j.ejphar.2005.04.040.

Abstract

To search for the pruritogen of atopic dermatitis, a characteristic symptom in atopic dermatitis patients, we examined interleukin-31 (IL-31) mRNA expression in NC/Nga mice as an animal model of atopic dermatitis. The expression of IL-31 mRNA in the skin of NC/Nga mice with scratching behavior was significantly higher than that in NC/Nga mice without scratching behavior. Our findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Dermatitis, Atopic / genetics*
  • Gene Expression / genetics*
  • Interleukins / genetics*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Pruritus / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Skin / metabolism
  • Skin / pathology
  • Specific Pathogen-Free Organisms
  • Transcription, Genetic / genetics

Substances

  • Interleukins
  • RNA, Messenger
  • interleukin-31, mouse