The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection

Amy J Myers; Brandon Eilertson; Scott A Fulton; Joanne L Flynn; David H Canaday

doi:10.1128/IAI.73.5.3192-3195.2005

The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection

Infect Immun. 2005 May;73(5):3192-5. doi: 10.1128/IAI.73.5.3192-3195.2005.

Authors

Amy J Myers¹, Brandon Eilertson, Scott A Fulton, Joanne L Flynn, David H Canaday

Affiliation

¹ Department of Medicine, Division of Infectous Disease, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4984, USA.

Abstract

The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tuberculosis was examined in a low-dose aerosol infection mouse model. P2X7(-/-) mice controlled infection in lungs as well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M. tuberculosis infection.

MeSH terms

Animals
Antigen Presentation
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Lung / immunology
Lung / microbiology
Lymph Nodes / immunology
Lymph Nodes / microbiology
Macrophages / immunology
Macrophages / microbiology
Mice
Mice, Inbred C57BL
Mycobacterium tuberculosis / pathogenicity*
Receptors, Purinergic P2 / metabolism*
Receptors, Purinergic P2X7
Tuberculosis, Pulmonary / immunology*
Tuberculosis, Pulmonary / microbiology

Substances

P2rx7 protein, mouse
Receptors, Purinergic P2
Receptors, Purinergic P2X7