Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy

Jon Infante; Javier Llorca; José Berciano; Onofre Combarros

doi:10.1016/j.jns.2004.09.023

Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy

J Neurol Sci. 2005 Jan 15;228(1):11-3. doi: 10.1016/j.jns.2004.09.023.

Authors

Jon Infante¹, Javier Llorca, José Berciano, Onofre Combarros

Affiliation

¹ Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain.

PMID: 15607204
DOI: 10.1016/j.jns.2004.09.023

Abstract

In a case-control study using a clinically well-defined group of 41 multiple system atrophy (MSA) patients and 93 control subjects, the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for MSA and, furthermore, this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype, suggesting a gene-gene interaction. These data support a role for inflammation-related genes in risk for MSA.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Case-Control Studies
Chi-Square Distribution
Female
Genotype
Humans
Intercellular Adhesion Molecule-1 / genetics*
Interleukin-8 / genetics*
Male
Middle Aged
Multiple System Atrophy / genetics*
Odds Ratio
Polymorphism, Genetic*
Risk*
Tumor Necrosis Factor-alpha / genetics*

Substances

Interleukin-8
Tumor Necrosis Factor-alpha
Intercellular Adhesion Molecule-1