Abstract
Expression of cardiac and gastric ghrelin messenger (m) RNA, together with heart and body weights, were measured in leptin-deficient (ob) and leptin receptor-deficient (db) mice with heart failure induced by viral myocarditis. Significant elevations in cardiac ghrelin mRNA levels and heart weight were observed in ob and db mice 10 days after viral inoculation compared with baseline values. Expression of gastric ghrelin mRNA was not upregulated in ob and db mice on day 10. The elevated expression of cardiac ghrelin mRNA seems to compensate for the lack of upregulation in gastric ghrelin mRNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Body Weight / genetics
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Gene Expression
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Ghrelin
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Heart / anatomy & histology
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Heart / physiology
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Heart Failure / etiology
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Heart Failure / genetics
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Leptin / deficiency*
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Leptin / genetics
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Leptin / metabolism
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Mice
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Mice, Inbred C3H
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Mice, Mutant Strains
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Myocarditis / complications
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Myocarditis / genetics*
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Myocarditis / pathology
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Peptide Hormones / genetics*
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Peptide Hormones / metabolism
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RNA, Messenger / metabolism
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Receptors, Cell Surface / deficiency*
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism
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Receptors, Leptin
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Stomach / physiology
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Up-Regulation
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Virus Diseases / complications
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Virus Diseases / genetics*
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Virus Diseases / pathology
Substances
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Ghrelin
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Leptin
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Peptide Hormones
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RNA, Messenger
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Receptors, Cell Surface
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Receptors, Leptin
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leptin receptor, mouse