Abstract
Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/beta-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Body Patterning / genetics*
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Cadherins / physiology
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Cytoskeletal Proteins / physiology*
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Embryonic and Fetal Development / genetics*
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Epidermal Growth Factor*
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Gene Expression Regulation / genetics*
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Growth Substances / genetics
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Membrane Glycoproteins*
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Mesoderm / physiology*
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Mice
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Mutagenesis
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Mutation
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Neoplasm Proteins / genetics*
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Proteins / genetics*
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Trans-Activators / physiology*
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Wnt Proteins
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Wnt3 Protein
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beta Catenin
Substances
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CTNNB1 protein, mouse
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Cadherins
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Cytoskeletal Proteins
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Growth Substances
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Membrane Glycoproteins
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Neoplasm Proteins
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Proteins
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Tdgf1 protein, mouse
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Trans-Activators
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Wnt Proteins
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Wnt3 Protein
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Wnt3 protein, mouse
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beta Catenin
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Epidermal Growth Factor