Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene

Genomics. 1992 Jun;13(2):475-8. doi: 10.1016/0888-7543(92)90277-y.

Abstract

A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR/FLK1 gene products and to a lesser degree to members of the class III RTKs: FMS/CSF1R, PDGFRA/B, KIT, and FLT3. The gene was named FLT4. Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R/PDGRFB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 5*
  • Genes
  • Humans
  • Mice / genetics*
  • Molecular Sequence Data
  • Multigene Family
  • Nucleic Acid Hybridization
  • Protein-Tyrosine Kinases / genetics*
  • Receptors, Cell Surface / genetics*
  • Sequence Alignment
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Vascular Endothelial Growth Factor Receptor-3

Substances

  • Receptors, Cell Surface
  • Protein-Tyrosine Kinases
  • Vascular Endothelial Growth Factor Receptor-3

Associated data

  • GENBANK/M74209
  • GENBANK/M74210
  • GENBANK/M74211
  • GENBANK/M74212
  • GENBANK/M74213
  • GENBANK/M74214
  • GENBANK/M74215
  • GENBANK/M76673
  • GENBANK/S41693
  • GENBANK/X69878