Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene

Nat Genet. 2003 Jul;34(3):261-2. doi: 10.1038/ng1171.

Abstract

MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosomes / genetics
  • Gene Expression Regulation, Developmental*
  • Genomic Imprinting*
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Mice
  • MicroRNAs / genetics*
  • Molecular Sequence Data
  • RNA, Antisense / genetics*
  • RNA, Untranslated
  • Retroelements / genetics*

Substances

  • Membrane Proteins
  • MicroRNAs
  • RNA, Antisense
  • RNA, Untranslated
  • Retroelements

Associated data

  • GENBANK/AJ517767
  • GENBANK/BK001261