Abstract
The 'signalling lymphocyte activation molecule' (SLAM) family is a newly appreciated group of immune-cell specific receptors that has the ability to regulate the function of several immune cell types. Recent studies show that the SLAM-related receptors mediate intracellular protein tyrosine phosphorylation signals. This property is dependent on the aptitude of SLAM-family receptors to bind with high affinity to SAP and/or EAT-2, two small adaptor molecules composed almost exclusively of a Src homology 2 domain. SAP is mutated in X-linked lymphoproliferative disease, a human immune dysfunction characterised by an inappropriate response to Epstein-Barr virus infection, thereby suggesting that the SLAM-related receptors may be critical for a normal immune response. The existence of the SLAM family broadens the spectrum of receptors known to be involved in immunomodulation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Adaptor Proteins, Vesicular Transport / metabolism
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Animals
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Antigens, CD
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Carrier Proteins / metabolism
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Glycoproteins / physiology*
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Humans
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Immunoglobulins / physiology*
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Intracellular Signaling Peptides and Proteins*
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Mice
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Receptors, Cell Surface
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Receptors, Immunologic / physiology*
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Signaling Lymphocytic Activation Molecule Associated Protein
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Signaling Lymphocytic Activation Molecule Family Member 1
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Transcription Factors / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Adaptor Proteins, Vesicular Transport
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Antigens, CD
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Carrier Proteins
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Glycoproteins
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Immunoglobulins
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Intracellular Signaling Peptides and Proteins
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Receptors, Cell Surface
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Receptors, Immunologic
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SH2D1A protein, human
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SH2D1B protein, human
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Sh2d1a protein, mouse
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Sh2d1b1 protein, mouse
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Signaling Lymphocytic Activation Molecule Associated Protein
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Transcription Factors
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Signaling Lymphocytic Activation Molecule Family Member 1