Abstract
The fibronectin type III (FNIII) repeat is one of three structural motifs originally identified in the fibronectin protein and has been well characterized in recent years. The consensus sequence has since been found in many different proteins including receptors and cell adhesion molecules. We report the cloning and expression analysis of Frcp1 and Frcp2, two members of a new FNIII repeat containing gene family. During embryonic development both genes are primarily expressed in the brain. In adult tissues, Frcp1 is strongly expressed in the liver and Frcp2 in the heart.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Blotting, Northern
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COS Cells
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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Embryo, Mammalian / metabolism
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Fibronectins / genetics*
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Gene Expression
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Gene Expression Regulation, Developmental
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Genes / genetics
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Green Fluorescent Proteins
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In Situ Hybridization
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Luminescent Proteins / genetics
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Luminescent Proteins / metabolism
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Male
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism
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Mice
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Mice, Inbred Strains
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Molecular Sequence Data
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Repetitive Sequences, Amino Acid / genetics*
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
Substances
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DNA, Complementary
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FNDC5 protein, mouse
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Fibronectins
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Frcp1 protein, mouse
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Luminescent Proteins
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Membrane Proteins
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RNA, Messenger
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Recombinant Fusion Proteins
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Green Fluorescent Proteins