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Page 1
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Nat Cell Biol. 2002 Sep;4(9):648-57. doi: 10.1038/ncb839.
Nat Cell Biol. 2002.
PMID: 12172553
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.
Sancak Y, et al.
Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003.
Mol Cell. 2007.
PMID: 17386266
Free article.
Item in Clipboard
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD.
Menon S, et al.
Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049.
Cell. 2014.
PMID: 24529379
Free PMC article.
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Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.
Deng L, Chen L, Zhao L, Xu Y, Peng X, Wang X, Ding L, Jin J, Teng H, Wang Y, Pan W, Yu F, Liao L, Li L, Ge X, Wang P.
Deng L, et al.
Cell Res. 2019 Feb;29(2):136-150. doi: 10.1038/s41422-018-0120-9. Epub 2018 Dec 4.
Cell Res. 2019.
PMID: 30514904
Free PMC article.
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Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.
Padi SKR, Singh N, Bearss JJ, Olive V, Song JH, Cardó-Vila M, Kraft AS, Okumura K.
Padi SKR, et al.
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20505-20510. doi: 10.1073/pnas.1904774116. Epub 2019 Sep 23.
Proc Natl Acad Sci U S A. 2019.
PMID: 31548394
Free PMC article.
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RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Li T, Wang X, Ju E, da Silva SR, Chen L, Zhang X, Wei S, Gao SJ.
Li T, et al.
Nat Commun. 2021 Feb 16;12(1):1055. doi: 10.1038/s41467-021-21206-3.
Nat Commun. 2021.
PMID: 33594058
Free PMC article.
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