Abstract
A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A represents a Type 1 membrane protein with homology with the CD2 family of receptors. A molecular model of the two predicted extracellular immunoglobulin-like domains of 19A has been generated using the crystal structure of CD2 as a template. In isolated lymphocytes, expression of 19A is induced by various activation stimuli, and enforced expression of the 19A gene promotes homotypic cell adhesion in a B-cell-line model. Collectively these data imply that the 19A protein plays a role in regulation of lymphocyte adhesion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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B-Lymphocytes / cytology
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B-Lymphocytes / metabolism*
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Base Sequence
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Blotting, Northern
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CD2 Antigens / chemistry*
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Cell Adhesion
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Cell Line
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Cloning, Molecular
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DNA, Complementary / metabolism
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Humans
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Immunoglobulins / chemistry*
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Lymphocyte Activation
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Models, Molecular
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Molecular Sequence Data
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Protein Structure, Tertiary
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RNA / metabolism
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Receptors, Immunologic / biosynthesis*
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Receptors, Immunologic / chemistry*
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Sequence Homology, Amino Acid
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Signaling Lymphocytic Activation Molecule Family
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Time Factors
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Tissue Distribution
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Transfection
Substances
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CD2 Antigens
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DNA, Complementary
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Immunoglobulins
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Receptors, Immunologic
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SLAMF7 protein, human
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Signaling Lymphocytic Activation Molecule Family
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RNA