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Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7176-81. doi: 10.1073/pnas.131188498. Epub 2001 Jun 5.
Proc Natl Acad Sci U S A. 2001.
PMID: 11390981
Free PMC article.
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
Wilson LFL, Dendooven T, Hardwick SW, Echevarría-Poza A, Tryfona T, Krogh KBRM, Chirgadze DY, Luisi BF, Logan DT, Mani K, Dupree P.
Wilson LFL, et al.
Nat Commun. 2022 Jun 8;13(1):3314. doi: 10.1038/s41467-022-31048-2.
Nat Commun. 2022.
PMID: 35676258
Free PMC article.
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