Abstract
We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Cell Line
-
Conserved Sequence
-
Female
-
Gene Library
-
Humans
-
Interleukin-17 / chemistry
-
Interleukin-17 / genetics*
-
Interleukin-17 / metabolism*
-
Interleukin-8 / biosynthesis
-
Kidney / immunology
-
Leukemia, Experimental / immunology
-
Leukemia, Experimental / virology
-
Male
-
Mice
-
Molecular Sequence Data
-
NF-kappa B / metabolism
-
Organ Specificity
-
Protein Isoforms / chemistry
-
Protein Isoforms / genetics
-
Protein Isoforms / metabolism
-
RNA, Messenger / genetics
-
Receptors, Interleukin / genetics
-
Receptors, Interleukin / metabolism*
-
Receptors, Interleukin-17
-
Recombinant Proteins / genetics
-
Recombinant Proteins / metabolism*
-
Recombinant Proteins / pharmacology
-
Sequence Alignment
-
Sequence Homology, Amino Acid
-
Transcription, Genetic
-
Transfection
-
Virus Integration
Substances
-
IL17RA protein, human
-
Il17ra protein, mouse
-
Interleukin-17
-
Interleukin-8
-
NF-kappa B
-
Protein Isoforms
-
RNA, Messenger
-
Receptors, Interleukin
-
Receptors, Interleukin-17
-
Recombinant Proteins