Abstract
Pheromones elicit specific behavioural responses and physiological alterations in recipients of the same species. In mammals, these chemical signals are recognized within the nasal cavity by sensory neurons that express pheromone receptors. In rodents, these receptors are thought to be represented by two large multigene families, comprising the V1r and V2r genes, which encode seven-transmembrane proteins. Although pheromonal effects have been demonstrated in humans, V1R or V2R counterparts of the rodent genes have yet to be characterized.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Animals
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Blotting, Southern
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Chemoreceptor Cells / chemistry*
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Chemoreceptor Cells / metabolism*
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Chemotactic Factors*
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Cloning, Molecular
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Codon
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Frameshift Mutation
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Glycosylation
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Humans
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Mice
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Models, Genetic
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Molecular Sequence Data
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Olfactory Mucosa / metabolism*
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Open Reading Frames
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Polymorphism, Single Nucleotide
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Rats
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Tissue Distribution
Substances
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Chemotactic Factors
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Codon
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V1ra1 protein, mouse
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VN1R1 protein, human