Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52

Cytogenet Cell Genet. 1999;87(1-2):85-8. doi: 10.1159/000015397.

Abstract

We report the sequence, tissue distribution, and chromosome location of a novel gene, PDCD9 (programmed cell death 9). PDCD9 is the mammalian counterpart of the Gallus gallus pro-apoptotic protein p52. The human cDNA has an open reading frame of 1,314 nucleotides and was predicted to encode a protein of 438 amino acids with a calculated mass of 50 kDa. The protein sequences of chicken, mouse, and human PDCD9 are remarkably conserved. PDCD9 mRNA is expressed ubiquitously in adult tissues, displaying a stronger signal in heart, skeletal muscle, kidney, and liver. PDCD9 was mapped to chromosome 5q11.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / genetics
  • Cell Cycle Proteins / chemistry*
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Chickens / genetics*
  • Chromosomes, Human, Pair 5 / genetics
  • Cloning, Molecular
  • Conserved Sequence / genetics
  • Expressed Sequence Tags
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mice
  • Molecular Sequence Data
  • Physical Chromosome Mapping*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Viral Proteins / chemistry*

Substances

  • Cell Cycle Proteins
  • RNA, Messenger
  • Viral Proteins
  • protein p52, mammalian

Associated data

  • GENBANK/AF146192