Structure and evolution of the extended B7 family

J Henry; M M Miller; P Pontarotti

doi:10.1016/s0167-5699(98)01418-2

Structure and evolution of the extended B7 family

Immunol Today. 1999 Jun;20(6):285-8. doi: 10.1016/s0167-5699(98)01418-2.

Authors

J Henry¹, M M Miller, P Pontarotti

Affiliation

¹ CNRS ER1794, Faculté de Médecine 87025 Limoges, France.

PMID: 10354554
DOI: 10.1016/s0167-5699(98)01418-2

Abstract

Here, Joëlle Henry and colleagues explore structural and evolutionary relationships between the B7 costimulator molecules and a growing number of molecules encoded within the major histocompatibility complex. They propose that B7 and MHC genes are derived from a common ancestor, with several members of this large gene family possibly having pivotal influences on T-cell activation.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Amino Acid Sequence
Animals
B7-1 Antigen / classification*
B7-1 Antigen / genetics*
B7-1 Antigen / physiology
Biological Evolution
Humans
Immunoglobulin Constant Regions / genetics
Immunoglobulin Variable Region / classification
Major Histocompatibility Complex / genetics
Molecular Sequence Data
Phylogeny
Sequence Alignment

Substances

B7-1 Antigen
Immunoglobulin Constant Regions
Immunoglobulin Variable Region