Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue

Genomics. 1999 Mar 15;56(3):340-3. doi: 10.1006/geno.1998.5712.

Abstract

Several different disease loci with unknown genetic background map to human Xp11. In a systematic search for novel genes, we identified a novel transcript, UXT (HGMW-approved symbol), close to the ELK1 locus in Xp11.23-p11.22. The gene is composed of seven exons and encodes a protein of 157 amino acids, which is highly conserved in mouse. We showed that UXT is ubiquitously expressed and subject to X-inactivation. No homology to any known genes was found. Database surveys indicate an abundant expression in tumor tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cell Cycle Proteins
  • Contig Mapping
  • Databases, Factual
  • Exons
  • Expressed Sequence Tags
  • Humans
  • Mice
  • Molecular Chaperones
  • Molecular Sequence Data
  • Myocardium / metabolism
  • Neoplasm Proteins / genetics*
  • Neoplasms / genetics
  • Polymerase Chain Reaction
  • Tissue Distribution
  • Tumor Cells, Cultured
  • X Chromosome / genetics*

Substances

  • Cell Cycle Proteins
  • Molecular Chaperones
  • Neoplasm Proteins
  • UXT protein, human

Associated data

  • GENBANK/AF092737
  • GENBANK/AF092738